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The alpha-emitter ²²⁵Ac (t_1/2 = 9.92 d) is currently under development for targeted alpha-particle therapy of cancer, and accelerator production of ²²⁵Ac via proton irradiation of thorium targets requires robust separations of ²²⁵Ac from chemically similar fission product lanthanides. Additionally, the lanthanide elements represent critical components in modern technologies, and radiolanthanides such as ¹⁴⁰Nd (t_1/2 = 3.37 d) also have potential application in the field of nuclear medicine. The ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Bmim][NTf₂]), combined with the diglycolamide extractant, N,N-dioctyldiglycolamic acid (DODGAA), was adsorbed on macroporous resin support to produce a solvent impregnated resin (SIR) that was investigated for separationsmore » of ²²⁵Ac and lanthanides. The equilibrium distribution coefficients (Kd) of the rare earth elements (Sc(III), Y(III), Ln(III)), ²²⁵Ac(III), Th(IV), and U(VI) on the prepared DODGAA/[Bmim][NTf₂]-SIR were determined from batch adsorption experiments in HCl and HNO₃ media. The DODGAA/[Bmim][NTf2]-SIR exhibited preferential uptake of the heavier lanthanide elements while allowing for the separation of the lighter lanthanides. Column separations utilizing the DODGAA/[Bmim][NTf₂]-SIR were effective at separating the lighter lanthanides from each other, and separating ²²⁵Ac from a mixture of lanthanides, ²¹³Bi, and ²²⁵Ra without the need for additional complexing agents.« less

Uranium-230 (t_1/2 = 20.8 d) is an alpha-emitting radionuclide that has potential application in targeted alpha therapy (TAT) of cancer. Its parent isotope ²³⁰Pa (t_1/2 = 17.4 d), can be produced by proton irradiation of thorium metal targets. Preliminary ²³⁰Pa production runs were performed at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF) using thin thorium metal targets and a proton beam energy of 15–30 MeV, followed by radiochemical separation of ²³⁰Pa from the irradiated target matrix. The measured ²³⁰Pa production yields were found to exceed the predicted values in most of the experiments that were performed. Furthermore, thismore » data will inform further production efforts for providing ²³⁰Pa/²³⁰U for clinical trials.« less